HERPES-SIMPLEX VIRUS IN IMMUNOCOMPROMISED PATIENTS - GROWING EVIDENCE OF DRUG-RESISTANCE

被引：33

作者：

EPSTEIN, JB ^{[1
]}

SCULLY, C ^{[1
]}

机构：

[1] UNIV BRISTOL,BRISTOL DENT SCH & HOSP,CTR STUDY ORAL DIS,DEPT ORAL MED,BRISTOL BS8 1TH,AVON,ENGLAND

来源：

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 1991年 / 72卷 / 01期

关键词：

D O I：

10.1016/0030-4220(91)90188-I

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Antiviral drugs have proven effective in treatment of herpesvirus infections and in prevention of reactivation of latent virus. The prototype drug is acyclovir. Herpes simplex virus (HSV) is susceptible to acyclovir. There is increasing evidence in immunocompromised patients of acyclovir-resistant HSV causing clinical disease. Mechanisms of HSV resistance to acyclovir are known. These findings have implications for the future development and clinical use of antiviral drugs.

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页码：47 / 50

页数：4

相关论文

共 70 条

[21] A COMPARATIVE-STUDY OF HERPES-SIMPLEX INFECTIONS IN RENAL-TRANSPLANT AND LEUKEMIC PATIENTS [J].

GREENBERG, MS ;

FRIEDMAN, H ;

COHEN, SG ;

OH, SH ;

LASTER, L ;

STARR, S .

JOURNAL OF INFECTIOUS DISEASES, 1987, 156 (02) :280-287

[22]

GREENSPAN D, 1987, J CALIFORNIA DENTAL, V15, P28

[23] ACYCLOVIR PROPHYLAXIS AGAINST HERPES-VIRUS INFECTIONS IN SEVERELY IMMUNOCOMPROMISED PATIENTS - RANDOMIZED DOUBLE-BLIND TRIAL [J].

HANN, IM ;

PRENTICE, HG ;

BLACKLOCK, HA ;

ROSS, MGR ;

BRIGDEN, D ;

ROSLING, AE ;

BURKE, C ;

CRAWFORD, DH ;

BRUMFITT, W ;

HOFFBRAND, AV .

BMJ-BRITISH MEDICAL JOURNAL, 1983, 287 (6389) :384-388

[24] CHRONIC PERIANAL HERPES-SIMPLEX IN IMMUNOCOMPROMISED HOSTS [J].

KALB, RE ;

GROSSMAN, ME .

AMERICAN JOURNAL OF MEDICINE, 1986, 80 (03) :486-490

[25] HISTORY, PHARMACOKINETICS, AND PHARMACOLOGY OF ACYCLOVIR [J].

KING, DH .

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1988, 18 (01) :176-179

[26]

LOZADA F, 1983, ORAL SURG ORAL MED O, V56, P481

[27] ACYCLOVIR-RESISTANT, FOSCARNET-SENSITIVE ORAL HERPES-SIMPLEX TYPE-2 LESION IN A PATIENT WITH AIDS [J].

MACPHAIL, LA ;

GREENSPAN, D ;

SCHIODT, M ;

DRENNAN, DP ;

MILLS, J .

ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1989, 67 (04) :427-432

[28] PREVALENCE AND INCIDENCE OF HERPESVIRUS INFECTIONS AMONG HOMOSEXUALLY ACTIVE MEN [J].

MANN, SL ;

MEYERS, JD ;

HOLMES, KL ;

COREY, L .

JOURNAL OF INFECTIOUS DISEASES, 1984, 149 (06) :1026-1027

[29]

MARCUSEN DC, 1985, LARYNGOSCOPE, V95, P401

[30] INVITRO SENSITIVITY TO ACYCLOVIR IN GENITAL HERPES-SIMPLEX VIRUSES FROM ACYCLOVIR-TREATED PATIENTS [J].

MCLAREN, C ;

COREY, L ;

DEKKET, C ;

BARRY, DW .

JOURNAL OF INFECTIOUS DISEASES, 1983, 148 (05) :868-875

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