INFLUENCE OF ADRENAL-STEROID HORMONES ON SODIUM APPETITE OF BALB/C MICE

被引：19

作者：

BLAIRWEST, JR ^{[1
]}

DENTON, DA ^{[1
]}

MCBURNIE, M ^{[1
]}

TARJAN, E ^{[1
]}

WEISINGER, RS ^{[1
]}

机构：

[1] UNIV MELBOURNE,HOWARD FLOREY INST EXPTL PHYSIOL & MED,PARKVILLE,VIC 3052,AUSTRALIA

来源：

APPETITE | 1995年 / 24卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0195-6663(95)80002-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The effects of adrenal steroid hormones on sodium appetite were determined in female Balb/c mice by the subcutaneous implantation for 7 days of slow-release pellets containing aldosterone, corticosterone, deoxycorticosterone (DOG) or 11-deoxycortisol, separately or in a ''cocktail'' combination. Placebo pellets were also implanted. The daily intake of 0.3 M NaCl was increased for 2 days by aldosterone (calculated 2.9 mu g/day released) or corticosterone (240 mu g/day) and for 7 days by DOC (4.8 mu g/day). The combination of these steroids plus 11-deoxycortisol (95 mu g/day) increased daily sodium intake nine-fold (days 3-7) and also increased water intake 1.5-fold. Placebo pellets had small effects on water intake on three days. Subcutaneous infusion of ACTH (Synacthen) at 2.8 mu g/day for 7 days by mini-osmotic pump increased sodium intake five-fold and water intake three- or four-fold. Thus, several adrenal steroids evoked sodium appetite in Balb/c mice, DOC being the most potent at the doses used. The effects of individual steroids are consistent with their contribution to the effect of ACTH on sodium appetite.

引用

页码：11 / 24

页数：14