STRUCTURE AND LIGAND RECOGNITION OF THE PHOSPHOTYROSINE BINDING DOMAIN OF SHC

被引：321

作者：

ZHOU, MM

RAVICHANDRAN, KS

OLEJNICZAK, ET

PETROS, AM

MEADOWS, RP

SATTLER, M

HARLAN, JE

WADE, WS

BURAKOFF, SJ

FESIK, SW

机构：

[1] ABBOTT LABS,DIV PHARMACEUT DISCOVERY,ABBOTT PK,IL 60064

[2] HARVARD UNIV,SCH MED,DANA FARBER CANC INST,DIV PEDIAT ONCOL,BOSTON,MA 02115

[3] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

NATURE | 1995年 / 378卷 / 6557期

关键词：

D O I：

10.1038/378584a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nuclear magnetic resonance structure of the phosphotyrosine binding (PTB) domain of Shc complexed to a phosphopeptide reveals an alternative means of recognizing tryosine-phosphorylated proteins. Unlike in SH2 domains, the phosphopeptide forms an antiparallel beta-strand with a beta-sheet of the protein, interacts with a hydrophobic pocket through the (pY-5) residue, and adopts a beta-turn. The PTB domain is structurally similar to pleckstrin homology domains (a alpha-sandwich capped by an alpha-helix) and binds to acidic phospholipids, suggesting a possible role in membrane localization.

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页码：584 / 592

页数：9

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