1',6'-METHANO CARBOCYCLIC THYMIDINE - SYNTHESIS, X-RAY CRYSTAL-STRUCTURE, AND EFFECT ON NUCLEIC-ACID DUPLEX STABILITY

被引：103

作者：

ALTMANN, KH ^{[1
]}

IMWINKELRIED, R ^{[1
]}

KESSELRING, R ^{[1
]}

RIHS, G ^{[1
]}

机构：

[1] DEPT PHYS,CH-4002 BASEL,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(00)78359-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound 1 has been synthesized via bicyclic lactone 3 and amine 9 as the key intermediates. X-ray crystallography reveals the bicyclic skeleton of 1 to adopt a boat-like (3'exo) conformation. Oligodeoxyribonucleotides incorporating up to 10 building blocks 1 in place of natural thymidine are still capable of binding to complementary DNA or RNA, albeit with lower affinity than the unmodified parent compounds.

引用

页码：7625 / 7628

页数：4

共 22 条

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