SODIUM ORTHO-VANADATE, A POWERFUL VASOCONSTRICTOR IN THE GILLS OF THE COMMON EEL, ANGUILLA-ANGUILLA

被引：11

作者：

BELL, MV

KELLY, KF

SARGENT, JR

机构：

[1] Institute of Marine Biochemistry, Aberdeen, Scotland

来源：

JOURNAL OF THE MARINE BIOLOGICAL ASSOCIATION OF THE UNITED KINGDOM | 1979年 / 59卷 / 02期

基金：

英国自然环境研究理事会;

关键词：

D O I：

10.1017/S0025315400042740

中图分类号：

Q17 [水生生物学];

学科分类号：

071004 ;

摘要：

Sodium orthovanadate added internally is a powerful vasoconstrictor in perfused, irrigated gills of Anguilla anguilla. The anion is active at concentrations as low as 10-7 M and its action is antagonized by β-adrenergic vasodilators such as adrenaline and isoprenaline. These effects are discussed in terms of the known mode of action of vanadate as an inhibitor of (Na++K+)-dependent ATPase. The biological and pharmacological effects of naturally occurring vanadate are assessed. © 1979, Marine Biological Association of the United Kingdom. All rights reserved.

引用

页码：429 / &

共 32 条

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