SYNTHESIS OF IMIDAZOLIDINEDIONES AND OXAZOLIDINEDIONES FROM CYCLIZATION OF PROPARGYLUREAS AND PROPARGYL CARBAMATES

被引:9
作者
CHIU, S [1 ]
KEIFER, L [1 ]
TIMBERLAKE, JW [1 ]
机构
[1] UNIV NEW ORLEANS,DEPT CHEM,NEW ORLEANS,LA 70122
关键词
D O I
10.1021/jm00192a026
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A synthetic procedure for the preparation of imidazolidinediones by the base-catalyzed cyclization of propargylureas is described. This method appears to be the most versatile way of obtaining these compounds containing tertiary groups substituted on ring-nitrogen number 3. One of these derivatives. 3-tert-butyl-5, 5-dimethyl-2, 4-imidazolidinedione (la), has shown a moderate level of subcutaneous metrazole seizure threshold activity (scMet indicates potential for control of petit mal epileptic seizures) in control screens on mice, as determined by the National Institute of Neurological and Communicative Disorders and Stroke. © 1979, American Chemical Society. All rights reserved.
引用
收藏
页码:746 / 748
页数:3
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