ISOLATION AND STRUCTURE ELUCIDATION OF 2 NEW CALPAIN INHIBITORS FROM STREPTOMYCES-GRISEUS

被引：25

作者：

ALVAREZ, ME

HOUCK, DR

WHITE, CB

BROWNELL, JE

BOBKO, MA

RODGER, CA

STAWICKI, MB

SUN, HH

GILLUM, AM

COOPER, R

机构：

[1] Sterling Winthrop Pharmaceutical Research Division, PA 19355, 25 Great Valley Parkway, Malvern

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 11期

关键词：

D O I：

10.7164/antibiotics.47.1195

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new peptides, a diketopiperazine of N-methyltyrosine (1) and a tetrapeptide containing N-methyltyrosine (2), were isolated from an actinomycete strain Streptomyces griseus. These compounds inhibit the enzyme calpain in the micromolar range and were characterized on the basis of spectroscopic analysis, amino acid analysis and sequencing. The structure of the tetrapeptide N-methyltyrosyl-N-methyltyrosyl-leucyl-alanine (2), was also confirmed by total synthesis.

引用

页码：1195 / 1201

页数：7

共 14 条

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