ANXIOGENIC-LIKE EFFECT OF INFUSING 1-(3-CHLOROPHENYL) PIPERAZINE (MCPP) INTO THE HIPPOCAMPUS

被引：88

作者：

WHITTON, P ^{[1
]}

CURZON, G ^{[1
]}

机构：

[1] INST NEUROL,DEPT NEUROCHEM,QUEEN SQ,LONDON WC1N 3BG,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1990年 / 100卷 / 01期

关键词：

1-(3-Chlorophenyl)piperazine (mCPP); 5-HT[!sub]1C[!/sub] receptor; Anxiety; Hippocampus; Rat; Social activity;

D O I：

10.1007/BF02245806

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

1-(3-Chlorophenyl) piperazine (mCPP) was previously shown to have an anxiogenic-like effect, i.e., it decreased total interaction in a rat social interaction test. Evidence indicated mediation by activation of 5-HT1C receptors with an ED50 of approximately 500 μg/kg IP (Kennett et al. 1989). A comparable effect is now shown on infusing 4 μg of the drug ICV or infusing 0.5 μg into the hippocampus. Both responses were dose dependent. Infusion of 1 μg mCPP into the amygdala had no effect. None of the above treatments significantly reduced locomotion. Results are consistent with the postulated role of the hippocampus in anxiety. © 1990 Springer-Verlag.

引用

页码：138 / 140

页数：3

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