SELECTIVE DELIVERY OF A GREATER AMOUNT OF METHOTREXATE TO REGIONAL LYMPH-NODES USING A NEW DOSAGE FORMULATION, METHOTREXATE ADSORBED ON ACTIVATED CARBON PARTICLES, IN RATS

被引：5

作者：

HAGIWARA, A ^{[1
]}

TAKAHASHI, T ^{[1
]}

SAWAI, K ^{[1
]}

SAKAKURA, C ^{[1
]}

YAMAGUCHI, M ^{[1
]}

OSAKI, K ^{[1
]}

TSUJIMOTO, H ^{[1
]}

OHYAMA, T ^{[1
]}

TOMODA, H ^{[1
]}

YAMAMOTO, A ^{[1
]}

MURANISH, S ^{[1
]}

机构：

[1] KYOTO COLL MED,DEPT BIOPHARMACEUT,YAMASHINA KU,KYOTO 607,JAPAN

来源：

ANTI-CANCER DRUGS | 1994年 / 5卷 / 02期

关键词：

METHOTREXATE; ACTIVATED CARBON; DRUG DISTRIBUTION; LYMPH NODE METASTASIS;

D O I：

10.1097/00001813-199404000-00009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A new dosage formulation (MTX-CH) comprising methotrexate (MTX) adsorbed onto a suspension of activated carbon particles was developed for the treatment of lymph node metastases. In vitro studies showed that activated carbon particles adsorbed a great amount of MTX. Subcutaneous injection of MTX-CH into the left hind foot pad of rats distributed a greater amount of MTX selectively to the regional lymph nodes (the left popliteal node and the para-aortic nodes) for a longer period of time than similar administration of MTX aqueous solution with a smaller amount of MTX distributed to the rest of the whole body.

引用

页码：194 / 198

页数：5

共 9 条

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