CDNA CLONING OF MURINE NRF2 GENE, CODING FOR A P45 NF-E2 RELATED TRANSCRIPTION FACTOR

被引：57

作者：

CHUI, DHK ^{[1
]}

TANG, WZ ^{[1
]}

ORKIN, SH ^{[1
]}

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,HOWARD HUGHES MED INST,DEPT PEDIAT,DIV HEMATOL,BOSTON,MA 02115

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 209卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.1467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A lambda gt11 cDNA library was constructed from poly-A rich RNA prepared from circulating murine yolk sac derived nucleated erythroblasts, on day 9 of gestation. In addition to the embryonic globin genes, this library was found to contain clones for the hematopoietic specific p45 NF-E2, as web as p18 NF-E2 and p45 NF-E2 related factor 1 (Nrf 1) genes. Using a degenerate oligonucleotide 17mer probe coding for a part of the highly conserved DNA binding domain for p45 NF-E2, we have isolated murine Nrf 2, a second murine homologue related to p45 NF-E2. The murine Nrf 2 gene is expressed not only in erythroid cells, but also in the 3T3 murine fibroblast cell line. (C) 1995 Academic Press, Inc.

引用

页码：40 / 46

页数：7

共 9 条

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