THE EFFECTS OF A RANGE OF ANTICANCER DRUGS IN THE WHITE-IVORY SOMATIC MUTATION TEST IN DROSOPHILA

被引：22

作者：

CLEMENTS, J

HOWE, D

LOWRY, A

PHILLIPS, M

机构：

[1] UNIV EXETER,WASHINGTON SINGER LABS,DEPT BIOL SCI,EXETER EX4 4QG,DEVON,ENGLAND

[2] TAUNTON & SOMERSET HOSP,MUSGROVE PK BRANCH,TAUNTON TA1 5DA,SOMERSET,ENGLAND

来源：

MUTATION RESEARCH | 1990年 / 228卷 / 02期

关键词：

D O I：

10.1016/0027-5107(90)90073-D

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The white-ivory test is based upon the reversion of the X-linked, recessive eye-colour mutation white-ivory to wild-type. Somatic reversion of white-ivory results in clones of red facets in the white-ivory eyes of eclosing adult files. 4 anti-cancer drugs, bleomycin, adriamycin, mitoxantrone and cyclophosphamide were found to significantly increase the white-ivory reversion frequency whereas cytosine arabinoside, methotrexate and vincristine did not give positive results. © 1990.

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页码：171 / 176

页数：6

相关论文

共 24 条

[1] THERAPY-RELATED LEUKEMIA - A REPORT OF 5 PATIENTS AND A REVIEW OF THE LITERATURE [J].

ADVANI, SH ;

DOVAL, DC ;

GOPAL, R ;

NAIR, CN ;

KUTTY, PM .

ONCOLOGY, 1983, 40 (04) :268-272

[2]

BOWMAN JT, 1965, GENETICS, V52, P1069

[3] THE DROSOPHILA WING TEST - A COMPARISON OF THE SENSITIVITY OF DIFFERENT STRAINS [J].

CLEMENTS, J ;

HOWE, D ;

PHILLIPS, M ;

TODD, NK .

MUTATION RESEARCH, 1988, 203 (02) :117-123

[4] ARISTOLOCHIC ACID IS MUTAGENIC AND RECOMBINOGENIC IN DROSOPHILA GENOTOXICITY TESTS [J].

FREI, H ;

WURGLER, FE ;

JUON, H ;

HALL, CB ;

GRAF, U .

ARCHIVES OF TOXICOLOGY, 1985, 56 (03) :158-166

[5]

GRAF U, 1984, ENVIRON MUTAGEN, V6, P153, DOI 10.1002/em.2860060206

[6] A PILOT-STUDY ON A NEW DROSOPHILA SPOT-TEST [J].

GRAF, U ;

JUON, H ;

KATZ, AJ ;

FREI, HJ ;

WURGLER, FE .

MUTATION RESEARCH, 1983, 120 (04) :233-239

[7]

GREEN M. M., 1959, HEREDITY, V13, P303, DOI 10.1038/hdy.1959.37

[8] GENETIC-MOLECULAR BASIS FOR A SIMPLE DROSOPHILA-MELANOGASTER SOMATIC SYSTEM THAT DETECTS ENVIRONMENTAL MUTAGENS [J].

GREEN, MM ;

TODO, T ;

RYO, H ;

FUJIKAWA, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (18) :6667-6671

[9] THE WHITE-IVORY SOMATIC MUTATION TEST IN DROSOPHILA - THE EFFECTS OF LARVAL AGE, INCREASING THE NUMBER OF COPIES OF WI AND THE RESPONSE TO SOME REFERENCE MUTAGENS [J].

HOWE, D ;

CLEMENTS, J .

MUTATION RESEARCH, 1990, 228 (02) :193-202

[10] A SMALL TANDEM DUPLICATION IS RESPONSIBLE FOR THE UNSTABLE WHITE-IVORY MUTATION IN DROSOPHILA [J].

KARESS, RE ;

RUBIN, GM .

CELL, 1982, 30 (01) :63-69