CLINICAL AND LABORATORY OUTCOMES DURING THE TREATMENT OF RHEUMATOID-ARTHRITIS WITH METHOTREXATE

Ten clinical and three laboratory outcomes were evaluated in 86 patients completing a double-blind placebo-controlled trial of methotrexate in rheumatoid arthritis. The improvement in all measured outcomes was statistically significantly better in patients receiving methotrexate than in patients receiving placebo. The correlations of the changes in outcome measures were calculated to determine if improvement in one parameter was associated with improvement in other clinical parameters. Associations between different clinical outcomes were often statistically significant. Associations between laboratory outcomes were also often statistically significant. However, the association between clinical outcomes and laboratory outcomes was generally poor. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.