学术探索
学术期刊
新闻热点
数据分析
智能评审
立即登录
CHANGING PATTERNS OF THE RETINOIC ACID SYSTEM IN THE DEVELOPING RETINA
被引:138
作者
:
MCCAFFERY, P
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
MCCAFFERY, P
POSCH, KC
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
POSCH, KC
NAPOLI, JL
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
NAPOLI, JL
论文数:
引用数:
h-index:
机构:
GUDAS, L
DRAGER, UC
论文数:
0
引用数:
0
h-index:
0
机构:
HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
DRAGER, UC
机构
:
[1]
HARVARD UNIV, SCH MED, DEPT NEUROBIOL, BOSTON, MA 02115 USA
[2]
SUNY Buffalo, DEPT BIOCHEM, BUFFALO, NY 14214 USA
[3]
CORNELL UNIV, SCH MED, DEPT PHARMACOL, NEW YORK, NY 10021 USA
来源
:
DEVELOPMENTAL BIOLOGY
|
1993年
/ 158卷
/ 02期
关键词
:
D O I
:
10.1006/dbio.1993.1197
中图分类号
:
Q [生物科学];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
In retinas of embryonic rat and chick, as in the mouse, synthesis of retinoic acid is mediated by different dehydrogenases in dorsal and ventral portions, with the ventral pathways generating higher retinoic acid levels. In the mouse, the dorsal enzyme was previously found to be the aldehyde dehydrogenase class-1 isoform AHD-2 and the ventral enzyme an unknown acidic dehydrogenase activity. This acidic dehydrogenase activity is now shown to consist of an early and a later expressed form, with the early form being indistinguishable from the activity in the early embryonic trunk and heart regions. Expression of the acidic dehydrogenase in the eye is first detected at the optic pit stage (E8.0), a day before the appearance of AHD-2 in the optic vesicle. The acidic dehydrogenase accounts for most of the retinoic acid synthesis in the retina during embryonic and early postnatal stages; during later postnatal stages it disappears and in the adult retina all retinoic acid synthesis is mediated by AHD-2. HPLC measurements in mice show high levels of all-trans- and 13-cis-retinoic acid: at E14 the retina contains a total of about 0.5 μM retinoic acid, and levels in the adult retina are about fourfold lower. The dorso-ventral asymmetry extends also to the cellular retinoic acid binding protein CRABP I, which first appears in the early differentiating ganglion cells in central retina and in the later embryo shows transiently a ventro-dorsally receding pattern of expression. © 1993 by Academic Press, Inc.
引用
收藏
页码:390 / 399
页数:10
相关论文
共 42 条
[41]
CONGENITAL MALFORMATIONS INDUCED IN RATS BY MATERNAL VITAMIN-A DEFICIENCY - .1. DEFECTS OF THE EYE
WARKANY, J
论文数:
0
引用数:
0
h-index:
0
WARKANY, J
SCHRAFFENBERGER, E
论文数:
0
引用数:
0
h-index:
0
SCHRAFFENBERGER, E
[J].
ARCHIVES OF OPHTHALMOLOGY,
1946,
35
(02)
: 150
-
169
[42]
AN ANALYSIS OF THE SYNDROME OF MALFORMATIONS INDUCED BY MATERNAL VITAMIN A DEFICIENCY - EFFECTS OF RESTORATION OF VITAMIN-A AT VARIOUS TIMES DURING GESTATION
WILSON, JG
论文数:
0
引用数:
0
h-index:
0
WILSON, JG
ROTH, CB
论文数:
0
引用数:
0
h-index:
0
ROTH, CB
WARKANY, J
论文数:
0
引用数:
0
h-index:
0
WARKANY, J
[J].
AMERICAN JOURNAL OF ANATOMY,
1953,
92
(02):
: 189
-
217
←
1
2
3
4
5
→
共 42 条
[41]
CONGENITAL MALFORMATIONS INDUCED IN RATS BY MATERNAL VITAMIN-A DEFICIENCY - .1. DEFECTS OF THE EYE
WARKANY, J
论文数:
0
引用数:
0
h-index:
0
WARKANY, J
SCHRAFFENBERGER, E
论文数:
0
引用数:
0
h-index:
0
SCHRAFFENBERGER, E
[J].
ARCHIVES OF OPHTHALMOLOGY,
1946,
35
(02)
: 150
-
169
[42]
AN ANALYSIS OF THE SYNDROME OF MALFORMATIONS INDUCED BY MATERNAL VITAMIN A DEFICIENCY - EFFECTS OF RESTORATION OF VITAMIN-A AT VARIOUS TIMES DURING GESTATION
WILSON, JG
论文数:
0
引用数:
0
h-index:
0
WILSON, JG
ROTH, CB
论文数:
0
引用数:
0
h-index:
0
ROTH, CB
WARKANY, J
论文数:
0
引用数:
0
h-index:
0
WARKANY, J
[J].
AMERICAN JOURNAL OF ANATOMY,
1953,
92
(02):
: 189
-
217
←
1
2
3
4
5
→