EXPRESSION OF BETA-AMYLOID PRECURSOR PROTEIN GENE IS DEVELOPMENTALLY-REGULATED IN HUMAN MUSCLE-FIBERS IN-VIVO AND IN-VITRO

被引：20

作者：

SARKOZI, E ^{[1
]}

ASKANAS, V ^{[1
]}

JOHNSON, SA ^{[1
]}

MCFERRIN, J ^{[1
]}

ENGEL, WK ^{[1
]}

机构：

[1] UNIV SO CALIF,SCH MED,ETHEL PERCY ANDRUS GERONTOL CTR,LOS ANGELES,CA 90089

来源：

EXPERIMENTAL NEUROLOGY | 1994年 / 128卷 / 01期

关键词：

D O I：

10.1006/exnr.1994.1109

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regenerating muscle fibers in 25 human muscle biopsies, obtained from patients with a variety of neuromuscular diseases, manifested increased mRNA for the beta-amyloid precursor protein (beta APP) that contains the Kunitz-type protease inhibitor (KPI) motif, whereas adult human muscle fibers were negative in their vast non-extrajunctional region. Aneurally cultured normal human muscle fibers also expressed strong KPI-beta APP mRNA signal, which became significantly downregulated during muscle differentiation. Our study demonstrates that in human muscle KPI-beta APP mRNA if developmentally regulated, and it suggests that beta APP may play a role in human muscle development. (C) 1994 Academic Press, Inc.

引用

页码：27 / 33

页数：7

共 47 条

[1]

ALVAREZ RB, 1990, J NEUROL SCI, V98, P178

[2] DENOVO NEUROMUSCULAR-JUNCTION FORMATION ON HUMAN-MUSCLE FIBERS CULTURED IN MONOLAYER AND INNERVATED BY FETAL-RAT SPINAL-CORD - ULTRASTRUCTURAL AND ULTRASTRUCTURAL-CYTOCHEMICAL STUDIES [J].

ASKANAS, V ;

KWAN, H ;

ALVAREZ, RB ;

ENGEL, WK ;

KOBAYASHI, T ;

MARTINUZZI, A ;

HAWKINS, EF .

JOURNAL OF NEUROCYTOLOGY, 1987, 16 (04) :523-537

[3] SYNERGISTIC INFLUENCE OF POLYPEPTIDE GROWTH-FACTORS ON CULTURED HUMAN-MUSCLE [J].

ASKANAS, V ;

GALLEZHAWKINS, G .

ARCHIVES OF NEUROLOGY, 1985, 42 (08) :749-752

[4]

ASKANAS V, 1992, AM J PATHOL, V141, P31

[5] STRONG IMMUNOREACTIVITY OF BETA-AMYLOID PRECURSOR PROTEIN, INCLUDING THE BETA-AMYLOID PROTEIN-SEQUENCE, AT HUMAN NEUROMUSCULAR-JUNCTIONS [J].

ASKANAS, V ;

ENGEL, WK ;

ALVAREZ, RB .

NEUROSCIENCE LETTERS, 1992, 143 (1-2) :96-100

[6] GLUCOCORTICOID INCREASES ACETYLCHOLINESTERASE AND ORGANIZATION OF THE POSTSYNAPTIC MEMBRANE IN INNERVATED CULTURED HUMAN MUSCLE [J].

ASKANAS, V ;

MCFERRIN, J ;

PARKMATSUMOTO, YC ;

LEE, CS ;

ENGEL, WK .

EXPERIMENTAL NEUROLOGY, 1992, 115 (03) :368-375

[7] BETA-AMYLOID PRECURSOR EPITOPES IN MUSCLE-FIBERS OF INCLUSION-BODY MYOSITIS [J].

ASKANAS, V ;

ALVAREZ, RB ;

ENGEL, WK .

ANNALS OF NEUROLOGY, 1993, 34 (04) :551-560

[8] NEW PROGRAM FOR INVESTIGATING ADULT HUMAN SKELETAL-MUSCLE GROWN ANEURALLY IN TISSUE-CULTURE [J].

ASKANAS, V ;

ENGEL, WK .

NEUROLOGY, 1975, 25 (01) :58-67

[9]

ASKANAS V, 1985, NEUROSCI LETT, V61, P231

[10]

ASKANAS V, 1992, HDB CLIN NEUROLOGY, P85

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