RITANSERIN ATTENUATES ANORECTIC, ENDOCRINE AND THERMAL RESPONSES TO D-FENFLURAMINE IN HUMAN VOLUNTEERS

被引：133

作者：

GOODALL, EM

COWEN, PJ

FRANKLIN, M

SILVERSTONE, T

机构：

[1] LITTLEMORE HOSP,MRC,CLIN PHARMACOL UNIT,OXFORD OX4 4XN,OXON,ENGLAND

[2] UNIV OXFORD,LITTLEMORE HOSP,DEPT PSYCHIAT,OXFORD OX4 4XN,ENGLAND

[3] ST BARTHOLOMEWS HOSP,COLL MED,DEPT PSYCHOL MED,LONDON EC1A 7BE,ENGLAND

来源：

PSYCHOPHARMACOLOGY | 1993年 / 112卷 / 04期

关键词：

D-FENFLURAMINE; RITANSERIN; FOOD INTAKE; PROLACTIN; BODY TEMPERATURE; HUMAN VOLUNTEERS;

D O I：

10.1007/BF02244895

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the role of the 5-HT (2/1C) receptor antagonist ritanserin on d-fenfluramine (d-FF) induced changes in food intake, prolactin (PRL) secretion and oral temperature in 12 healthy male volunteers. The study was double blind and placebo controlled. Food intake was measured using an automated food dispenser. d-FF (30 mg) significantly reduced fat intake. While ritanserin (5 mg) had no effect when given alone it abolished the d-FF induced reduction in fat intake. In addition, ritanserin abolished the d-FF induced rise in PRL and oral temperature. The results suggest that 5-HT2 or 5-HTIC receptors mediate the effects of d-fenfluramine on appetite, prolactin secretion and temperature in humans.

引用

页码：461 / 466

页数：6

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