ADEQUACY OF MEASUREMENTS IN COMPARTMENTAL MODELING OF METABOLIC SYSTEMS

被引：10

作者：

BROWN, RF ^{[1
]}

CARSON, ER ^{[1
]}

FINKELSTEIN, L ^{[1
]}

GODFREY, KR ^{[1
]}

JONES, RP ^{[1
]}

机构：

[1] UNIV WARWICK,INTERUNIV INST ENGN CONTROL,DEPT ENGN,COVENTRY CV4 7AL,WARWICKSHIRE,ENGLAND

来源：

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING | 1979年 / 17卷 / 02期

关键词：

Metabolic systems; Modelling;

D O I：

10.1007/BF02440932

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

The adequacy of present-day measurement techniques for the compartmental modelling of metabolic systems is investigated using numerical examples and analysis of experimentally-obtained plasma clearance curves. It is concluded that the model parameters obtained are often of questionable accuracy. The situation can be improved by careful monitoring of experimental conditions and judicious spacing of data points on the response curve, but the work shows a clear need for a continuous (or semicontinuous) method of monitoring plasma concentration. To resolve ambiguities between models equally plausible on physiological grounds, it is necessary to monitor the dynamics of internal variables, for example, of the concentration in the liver (which is nowadays possible noninvasively). © 1979 IFMBE.

引用

页码：216 / 222

页数：7

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