AMILORIDE-DEPENDENT TRANSPORT IS THE MAIN MECHANISM IMPLICATED IN SODIUM INFLUX REGULATION IN RAT MAST-CELLS

被引：10

作者：

CABADO, AG

VIEYTES, MR

BOTANA, LM

机构：

[1] FAC VET LUGO,DEPT FARMACOL,E-27002 LUGO,SPAIN

[2] FAC VET LUGO,DEPT FISIOL,E-27002 LUGO,SPAIN

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 1993年 / 156卷 / 03期

关键词：

D O I：

10.1002/jcp.1041560316

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mast cell sodium regulation is a largely unknown field. In our effort to study the mechanisms by which mast cells regulate sodium levels, we have examined the effect of amiloride and ouabain on Na-22 entry in rat mast cells in isotonic and hypertonic conditions. Ouabain (0.5 mM) enhances sodium uptake by 32% in isotonic conditions. Hypertonicity increases by 400% the uptake of sodium through an amiloride (1 mM) dependent mechanism. Ouabain has no appreciable effect on the entry of Na-22 in hypertonic conditions. (C) 1993 Wiley-Liss, Inc.

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页码：567 / 570

页数：4

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