DE-NOVO PURINE NUCLEOTIDE BIOSYNTHESIS

被引:112
作者
ZALKIN, H
DIXON, JE
机构
[1] Department of Biochemistry, Purdue University, West Lafayette
来源
PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY | 1992年 / 42卷
关键词
D O I
10.1016/S0079-6603(08)60578-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This chapter discusses the recent progress made in understanding de novo purine nucleotide biosynthesis and its regulation in bacteria. A purR-encoded repressor—operator interaction plays a key role in the genetic regulation of purine biosynthesis in E. coli and also appears to be involved in coordinating the expression of genes in related metabolic pathways. The outline of a more complex regulatory system has been described for de novo purine nucleotide synthesis in B. subtilis. These advances have resulted from the cloning and analyses of structural genes encoding the biosynthetic enzymes and the purR regulatory gene from E. coli. The cloning of regulatory genes is essential for a further understanding of the regulation of purine nucleotide biosynthesis in B. subtilis. © 1992 Academic Press Inc.
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页码:259 / 287
页数:29
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