SOLID-PHASE SYNTHESIS OF PEPTIDE PARA-NITROANILIDES

被引：23

作者：

BURDICK, DJ

STRUBLE, ME

BURNIER, JP

机构：

[1] Department of Bioorganic Chemistry, Genentech Inc., South San Francisco, CA 94080

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 16期

关键词：

D O I：

10.1016/S0040-4039(00)77632-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile synthesis of peptide para -nitroanilides was developed using a novel urethane linked para -aminoanilide resin 3 and solid phase peptide synthesis. Conversion of the resulting peptide para -aminoanilides to the corresponding peptide para -nitroanilides was achieved by oxidation with sodium perborate. With the exception of sequences containing methionine, tryptophan and cysteine, all amino acid residues can be used. A representative synthesis of the tetrapeptide para -nitroanilide succinyl-Ala-Ala-Pro-Arg-PNA is described.

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页码：2589 / 2592

页数：4

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