CYCLOSPORINE - A LI-SPECIFIC AND CA-SPECIFIC IONOPHORE

被引：18

作者：

BURGER, HM ^{[1
]}

SEEBACH, D ^{[1
]}

机构：

[1] ETH ZENTRUM,ORGAN CHEM LAB,CH-8092 ZURICH,SWITZERLAND

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1994年 / 33卷 / 04期

关键词：

D O I：

10.1002/anie.199404421

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ionophoric properties of cyclosporin shed new light on its role in immunosuppresion: Cyclosporin transports Li+ and Ca2+ significantly faster than appropriate for their position in the series of alkali metal and alkaline‐earth metal ions, respectively. The migration of the picrates of these metals through a CH2Cl2 solution of cyclosporin (which functions as a liquid membrane) has been examined. Copyright © 1994 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：442 / 444

页数：3

共 31 条

[1] BAKKER E, 1994, IN PRESS ANAL CHEM, V66
[2] CYCLIC OCTAPEPTIDES AND DECAPEPTIDES AS IONOPHORES FOR MAGNESIUM
BEHM, F
AMMANN, D
SIMON, W
BRUNFELDT, K
HALSTROM, J
[J]. HELVETICA CHIMICA ACTA, 1985, 68 (01) : 110 - 118
[3] PREPARATION OF DIAMIDES AND TRIAMIDES AND THEIR APPLICATION IN ION-SELECTIVE ELECTRODES
BOCHENSKA, M
BIERNAT, JF
BRADSHAW, JS
[J]. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1991, 10 (01): : 19 - 27
[4] BOREL JF, 1989, PHARMACOL REV, V41, P239
[5] CATION-TRANSPORT ACROSS BULK LIQUID ORGANIC MEMBRANES WITH OLIGOMERS OF (R)-3-HYDROXYBUTANOIC ACID
BURGER, HM
SEEBACH, D
[J]. HELVETICA CHIMICA ACTA, 1993, 76 (07) : 2570 - 2580
[6] HOFMEISTER F, 1888, N-S ARCH EXP PATH PH, V24, P247
[7] MACROCYCLE-FACILITATED TRANSPORT OF IONS IN LIQUID MEMBRANE SYSTEMS
IZATT, RM
CLARK, GA
BRADSHAW, JS
LAMB, JD
CHRISTENSEN, JJ
[J]. SEPARATION AND PURIFICATION METHODS, 1986, 15 (01): : 21 - 72
[8] COMPARATIVE-STUDY OF MONO-SUBSTITUTED AND DISUBSTITUTED 14-CROWN-4 DERIVATIVES AS LITHIUM IONOPHORES
KATAKY, R
NICHOLSON, PE
PARKER, D
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1990, (02): : 321 - 327
[9] COMPARATIVE PERFORMANCE OF 14-CROWN-4 DERIVATIVES AS LITHIUM-SELECTIVE ELECTRODES
KATAKY, R
NICHOLSON, PE
PARKER, D
COVINGTON, AK
[J]. ANALYST, 1991, 116 (02) : 135 - 140
[10] COMPLEXATION AND MEDIUM EFFECTS ON THE CONFORMATION OF CYCLOSPORINE-A STUDIED BY NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS CALCULATIONS
KESSLER, H
GEHRKE, M
LAUTZ, J
KOCK, M
SEEBACH, D
THALER, A
[J]. BIOCHEMICAL PHARMACOLOGY, 1990, 40 (01) : 169 - 173

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