LASTING IMPACT OF A SINGLE BENZYLPYRENE TREATMENT IN PRENATAL AND GROWING AGE ON THE THYMIC GLUCOCORTICOID RECEPTORS OF RATS

被引:21
作者
CSABA, G [1 ]
INCZEFIGONDA, A [1 ]
SZEBERENYI, S [1 ]
机构
[1] NATL INST OCCUPAT HYG,BUDAPEST,HUNGARY
来源
GENERAL PHARMACOLOGY | 1991年 / 22卷 / 05期
关键词
D O I
10.1016/0306-3623(91)90212-O
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Rats exposed to benzpyrene in utero at 19 days of pre-natal life showed a relative decrease in the number of thymic glucocorticoid receptors at 6 weeks of age. 2. Primary exposure to benzpyrene at 6 weeks of age had a similar effect on females 4 weeks later, but did not change the glucocorticoid receptor number of males. 3. In utero exposure accounted for an increase in the fetal cytochrome P450 level within 1 day, whereas exposure at 6 weeks of age did not change it within 4 weeks. 4. It appears that exposure to benzpyrene gives rise to a faulty imprinting of the thymic glucocorticoid receptor in both fetal and growing age, to judge from a lasting change in the receptor number.
引用
收藏
页码:815 / 818
页数:4
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