THIN-LAYER REVERSED-PHASE ION-PAIR CHROMATOGRAPHY OF SOME SULFONAMIDES

被引：11

作者：

BIEGANOWSKA, ML

PETRUCZYNIK, A

DORACZYNSKASZOPA, A

机构：

[1] Department of Inorganic and Analytical Chemistry, Medical Academy, 20081 Lublin

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1993年 / 11卷 / 03期

关键词：

REVERSED-PHASE ION-PAIR CHROMATOGRAPHY; ISOCRATIC ELUTION; GRADIENT ELUTION; CATIONIC COUNTERIONS; ANIONIC COUNTERIONS; SULFONAMIDES;

D O I：

10.1016/0731-7085(93)80203-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The retention behaviour of 15 sulphonamides was investigated by thin-layer reversed-phase ion-pair chromatography (RP-IPC). Optimization of the retention and selectivity of these compounds was carried out by changing the pH, the concentration of the ion-pairing counter-ion and the concentration of the organic solvent in the aqueous mobile phase. The effects of various cationic and anionic pairing reagents in the mobile phase and the stationary phase were investigated. The use of stepwise gradient elution improved the spot shape and the selectivity of the separation.

引用

页码：241 / 246

页数：6

共 27 条

[1]

BIAGI SL, 1975, J CHROMATOGR, V206, P349

[2] SEPARATION OF IONIC COMPOUNDS BY REVERSED-PHASE LIQUID-CHROMATOGRAPHY - AN UPDATE OF ION-PAIRING TECHNIQUES [J].