VECTORIZED TRANSPORT OF DRUGS - SYNTHESIS OF A NEW GLYCOSYL DERIVATIVE OF BETA-CYCLODEXTRIN

被引：53

作者：

PARROTLOPEZ, H ^{[1
]}

GALONS, H ^{[1
]}

COLEMAN, AW ^{[1
]}

MAHUTEAU, J ^{[1
]}

MIOCQUE, M ^{[1
]}

机构：

[1] UNIV PARIS SUD,CTR PHARMACEUT,CHIM ORGAN LAB,F-92296 CHATENAY MALABRY,FRANCE

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 02期

关键词：

BETA-CYCLODEXTRIN; SYNTHESIS; SPACER; BETA-GLYCOSAMIDE;

D O I：

10.1016/0040-4039(92)88052-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Monosubstitution at the O-6 position of beta-cyclodextrin by a beta-N-glucosyl residue has been achieved with a spacer C-9 diamide as the interglycosidic linkage. The new glycosyl derivative has been characterised by H-1 N.M.R. (COSY-RCT), is much more soluble (200g.1(1)) in water and has been shown to retain the capacity to include and to enhance the solubility of pharmacologically active molecules.

引用

页码：209 / 212

页数：4

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