USE OF 2-TRIMETHYLSILYLETHYL AS A PROTECTING GROUP IN PHOSPHATE MONOESTER SYNTHESIS

被引：21

作者：

SAWABE, A ^{[1
]}

FILLA, SA ^{[1
]}

MASAMUNE, S ^{[1
]}

机构：

[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 50期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0040-4039(93)88016-C

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A model study has demonstrated that phosphorylation of a highly hindered hydroxyl group can be achieved via sequential treatment with (1) 2-trimethylsilylethyl dichlorophosphite, (2) 2-trimethylsilylethyl alcohol, and (3) hydrogen peroxide. The resulting triester survives a variety of reaction conditions but may be cleaved with fluoride ion to afford the phosphate monoester.

引用

页码：7685 / 7686

页数：2

共 17 条

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