EFFECT OF LYSOPHOSPHATIDIC ACID ON THE PREIMPLANTATION DEVELOPMENT OF MOUSE EMBRYOS

被引：56

作者：

KOBAYASHI, T ^{[1
]}

YAMANO, S ^{[1
]}

MURAYAMA, S ^{[1
]}

ISHIKAWA, H ^{[1
]}

TOKUMURA, A ^{[1
]}

AONO, T ^{[1
]}

机构：

[1] UNIV TOKUSHIMA, FAC PHARMACEUT SCI, TOKUSHIMA 770, JAPAN

来源：

FEBS LETTERS | 1994年 / 351卷 / 01期

关键词：

EMBRYO; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; MOUSE;

D O I：

10.1016/0014-5793(94)00815-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of lysophosphatidic acid (LPA) on the preimplantation development of mouse embryos was examined. The blastocyst rates from 2-cell and 4-cell stage embryos were significantly higher in the presence of LPA at the pronuclear stage. However, the blastocyst rate from 4-cell stage embryos was significantly lower when LPA was added to the medium at the 4-cell stage than when it was added at the pronuclear stage. Furthermore, pretreatment of pronuclear stage embryos with pertussis toxin suppressed LPA-induced embryo development, suggesting that it is probably mediated by a Gi-protein-linked receptor.

引用

页码：38 / 40

页数：3

共 18 条

[1] SIGNALING PROPERTIES OF LYSOPHOSPHATIDIC ACID [J].

DURIEUX, ME ;

LYNCH, KR .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (06) :249-254

[2] LYSOPHOSPHATIDIC ACID INDUCES A PERTUSSIS TOXIN-SENSITIVE CA2+-ACTIVATED CL- CURRENT IN XENOPUS-LAEVIS OOCYTES [J].

DURIEUX, ME ;

SALAFRANCA, MN ;

LYNCH, KR ;

MOORMAN, JR .

AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (04) :C896-C900

[3] PHOSPHATIDIC-ACID AND LYSOPHOSPHATIDIC ACID STIMULATE RECEPTOR-REGULATED MEMBRANE CURRENTS IN THE XENOPUS-LAEVIS OOCYTE [J].

FERGUSON, JE ;

HANLEY, MR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 297 (02) :388-392

[4] LYSOPHOSPHATIDIC ACID INDUCES INWARD CURRENTS IN XENOPUS-LAEVIS OOCYTES - EVIDENCE FOR AN EXTRACELLULAR SITE OF ACTION [J].

FERNHOUT, BJH ;

DIJCKS, FA ;

MOOLENAAR, WH ;

RUIGT, GSF .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 213 (02) :313-315

[5]

GERRARD JM, 1979, AM J PATHOL, V96, P423

[6]

HARRIS AM, 1982, NATURE, V299, P460

[7] INSULIN-LIKE GROWTH FACTOR-I STIMULATES GROWTH OF MOUSE PREIMPLANTATION EMBRYOS INVITRO [J].

HARVEY, MB ;

KAYE, PL .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1992, 31 (03) :195-199

[8] INSULIN STIMULATES PROTEIN-SYNTHESIS IN COMPACTED MOUSE EMBRYOS [J].

HARVEY, MB ;

KAYE, PL .

ENDOCRINOLOGY, 1988, 122 (03) :1182-1184

[9] MEDIATION OF THE ACTIONS OF INSULIN AND INSULIN-LIKE GROWTH FACTOR-I ON PREIMPLANTATION MOUSE EMBRYOS INVITRO [J].

HARVEY, MB ;

KAYE, PL .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1992, 33 (03) :270-275

[10]

JALINK K, 1990, J BIOL CHEM, V265, P12232

← 1 2 →