IMPAIRMENT OF ACUTE PHASE PROTEIN REACTIVITY IN CHRONIC RENAL-FAILURE

被引：6

作者：

CHARLESWORTH, JA ^{[1
]}

QUIN, JW ^{[1
]}

HOLLOWAY, RH ^{[1
]}

JONES, BF ^{[1
]}

ROBERTSON, MR ^{[1
]}

机构：

[1] UNIV NEW S WALES, SYDNEY, NEW S WALES, AUSTRALIA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 59卷 / 04期

关键词：

D O I：

10.1159/000232289

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The acute phase protein response was studied after elective surgery in 13 normal subjects and 9 patients with severe chronic renal failure. Total haemolytic complement reactivity (CH50) and serum concentrations of C1q, C1s, C4, C3, factor B, properdin, C5, C9, C-reactive protein (CRP), caeruloplasmin, α1-acid glycoprotein and haptoglobin were measured preoperatively and on days 2, 4 and 6 after operation. Abnormalities were seen in the group with chronic renal failure. Firstly, there was no significant acute phase response of C1s, C3, C5, C9 and CH50 and a significant reduction in the response of factor B. Secondly, CRP showed prolonged elevation in the post-operative period in contrast to the transient rise seen in the control group. With the possible exception of α1-acid glycoprotein, the behaviour of the non-complement proteins (caeruloplasmin and haptoglobin) was comparable for the two groups. These defects could impair the physiologicl response to infection in patients with severe chronic renal failure.

引用

页码：420 / 426

页数：7