ISOLATION AND CHARACTERIZATION OF SHEEP LACTOFERRIN, AN INHIBITOR OF PLATELET-AGGREGATION AND COMPARISON WITH HUMAN LACTOFERRIN

被引:34
作者
QIAN, ZY [1 ]
JOLLES, P [1 ]
MIGLIORESAMOUR, D [1 ]
FIAT, AM [1 ]
机构
[1] UNIV PARIS 05,PROT LAB,CNRS,URA 1188,F-75270 PARIS 06,FRANCE
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 1995年 / 1243卷 / 01期
关键词
LACTOFERRIN; PLATELET AGGREGATION; MILK; SHEEP;
D O I
10.1016/0304-4165(94)00126-I
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Highly purified sheep lactoferrin was isolated from ovine whey in a single chromatographic step (FPLC): it was characterized by electrophoresis, N-terminal sequence determination and compared with lactoferrins from other species. Sheep and human lactoferrins inhibited thrombin-induced platelet aggregation (median inhibitory concentration: IC50 5 and 4 mu M, respectively). Pepsin hydrolysates of human and sheep lactoferrins were fractionated by reverse-phase high-performance liquid chromatography and only one peak was an inhibitor of platelet aggregation. The sheep or human lactoferrin binding to platelets was studied.
引用
收藏
页码:25 / 32
页数:8
相关论文
共 42 条
[1]   STRUCTURE OF HUMAN LACTOFERRIN AT 3.2-A RESOLUTION [J].
ANDERSON, BF ;
BAKER, HM ;
DODSON, EJ ;
NORRIS, GE ;
RUMBALL, SV ;
WATERS, JM ;
BAKER, EN .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (07) :1769-1773
[2]   ISOLATION AND PARTIAL CHARACTERIZATION OF OVINE LACTOFERRIN [J].
BAER, A ;
OROZ, M ;
BLANC, B .
EXPERIENTIA, 1979, 35 (12) :1554-1555
[3]   TRANSFERRINS - INSIGHTS INTO STRUCTURE AND FUNCTION FROM STUDIES ON LACTOFERRIN [J].
BAKER, EN ;
RUMBALL, SV ;
ANDERSON, BF .
TRENDS IN BIOCHEMICAL SCIENCES, 1987, 12 (09) :350-353
[4]   ANTIBACTERIAL SPECTRUM OF LACTOFERRICIN-B, A POTENT BACTERICIDAL PEPTIDE DERIVED FROM THE N-TERMINAL REGION OF BOVINE LACTOFERRIN [J].
BELLAMY, W ;
TAKASE, M ;
WAKABAYASHI, H ;
KAWASE, K ;
TOMITA, M .
JOURNAL OF APPLIED BACTERIOLOGY, 1992, 73 (06) :472-479
[5]   IDENTIFICATION OF THE BACTERICIDAL DOMAIN OF LACTOFERRIN [J].
BELLAMY, W ;
TAKASE, M ;
YAMAUCHI, K ;
WAKABAYASHI, H ;
KAWASE, K ;
TOMITA, M .
BIOCHIMICA ET BIOPHYSICA ACTA, 1992, 1121 (1-2) :130-136
[6]   ISOLATION AND CHARACTERIZATION OF LACTOFERRIN SEPARATED FROM HUMAN WHEY BY ADSORPTION CHROMATOGRAPHY USING CIBACRON BLUE F3G-A LINKED AFFINITY ADSORBENT [J].
BEZWODA, WR ;
MANSOOR, N .
CLINICA CHIMICA ACTA, 1986, 157 (01) :89-93
[8]   OVINE LACTOFERRIN - ISOLATION FROM COLOSTRUM AND CHARACTERIZATION [J].
BUCHTA, R .
JOURNAL OF DAIRY RESEARCH, 1991, 58 (02) :211-218
[9]   HUMAN-LEUKOCYTE ELASTASE, CATHEPSIN-G, AND LACTOFERRIN - FAMILY OF NEUTROPHIL GRANULE GLYCOPROTEINS THAT BIND TO AN ALVEOLAR MACROPHAGE RECEPTOR [J].
CAMPBELL, EJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (22) :6941-6945
[10]   STRUCTURE OF THE RECOMBINANT N-TERMINAL LOBE OF HUMAN LACTOFERRIN AT 2.0-ANGSTROM RESOLUTION [J].
DAY, CL ;
ANDERSON, BF ;
TWEEDIE, JW ;
BAKER, EN .
JOURNAL OF MOLECULAR BIOLOGY, 1993, 232 (04) :1084-1100