IDENTIFICATION OF NOVEL CDNAS ENCODING HUMAN KEXIN-LIKE PROTEASE, PACE4 ISOFORMS

被引：37

作者：

TSUJI, A

HIGASHINE, K

HINE, C

MORI, K

TAMAI, Y

NAGAMUNE, H

MATSUDA, Y

机构：

[1] Univ Tokushima, Fac Engn, Dept Biol Sci and Technol, Tokushima

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 200卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.1541

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PACE4 has been identified as a second human subtilisin-like protease by Keifer et al. [DNA and Cell Biology (1991) 10, 757-769]. In this study, we isolated two novel cDNAs coding for PACE4 isoforms (PACE4C and PACE4D) from a human placenta cDNA library. The deduced PACE4C protein sequence (652 amino acids) lacks the cysteine-rich region located at the carboxy terminus of PACE4. The DNA sequence of the 3'-untranslated region (1 kb) of PACE4C is not homologous to the PACE4 sequence. The protein (497 amino acids) encoded by PACE4D cDNA lacks a signal peptide, a propeptide and the cysteine-rich region. These isoform cDNAs were also isolated from rat pituitary cDNA library. (C) 1994 Academic Press, Inc.

引用

页码：943 / 950

页数：8

共 18 条

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