REDUCED GASTROINTESTINAL ABSORPTION OF CALCIUM IN DEMENTIA

被引：37

作者：

FERRIER, IN

LEAKE, A

TAYLOR, GA

MCKEITH, IG

FAIRBAIRN, AF

ROBINSON, CJ

FRANCIS, RM

EDWARDSON, JA

机构：

[1] NEWCASTLE GEN HOSP, BRIGHTON CLIN, DEPT OLD AGE PSYCHIAT, NEWCASTLE UPON TYNE NE4 6BE, TYNE & WEAR, ENGLAND

[2] NEWCASTLE GEN HOSP, DEPT GERIATR, NEWCASTLE UPON TYNE NE4 6BE, TYNE & WEAR, ENGLAND

[3] UNIV NEWCASTLE UPON TYNE, SCH MED, DEPT PHYSIOL SCI, NEWCASTLE UPON TYNE NE1, ENGLAND

来源：

AGE AND AGEING | 1990年 / 19卷 / 06期

关键词：

D O I：

10.1093/ageing/19.6.368

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Several reports have suggested that the neurodegenerative change in Alzheimer-type dementia (ATD) may be related to alterations in calcium homoeostasis. The absorption of radiocalcium (4SCa) in 26 ATD subjects and 11 patients with multi-infarct dementia (MID) was compared to 24 normal age- and sex-matched controls. The absorption of radiocalcium was significantly lower in both ATD and MID when compared to controls. The reduced 45Ca absorption in ATD occurred in the presence of normal plasma concentrations of PTH and vitamin D metabolites and the serum concentrations of calcium and aluminium were in the normal range. The data suggest that the reduced uptake of radioactive calcium observed in ATD is a non-specific derangement. © 1990 British Geriatrics Society.

引用

页码：368 / 375

页数：8

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