IN-VITRO DRUG-INTERACTION BETWEEN AMANTADINE AND CLASSICAL ANTIMALARIAL-DRUGS IN PLASMODIUM-FALCIPARUM INFECTIONS

被引：8

作者：

EVANS, SG ^{[1
]}

HAVLIK, I ^{[1
]}

机构：

[1] UNIV WITWATERSRAND,SCH MED,DEPT EXPTL & CLIN PHARMACOL,JOHANNESBURG 2193,SOUTH AFRICA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1994年 / 88卷 / 06期

关键词：

D O I：

10.1016/0035-9203(94)90229-1

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The interactions of amantadine with classical antimalarial drugs were evaluated against a chloroquine-resistant and a chloroquine-sensitive strain of Plasmodium falciparum in vitro. Amantadine potentiated the effect of chloroquine and quinine in both strains; it also potentiated the effect of mefloquine, halofantrine and primaquine in the chloroquine-resistant strain but had no effect in the chloroquine-sensitive strain. Amantadine had no effect on the response to pyrimethamine of either strain. Amantadine does not interfere with the activity of these compounds and may possibly enhance it.

引用

页码：683 / 686

页数：4

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