INHIBITION BY CAPSAICIN AGAINST CYCLOPHOSPHAMIDE-INDUCED CLASTOGENICITY AND DNA-DAMAGE IN MICE

被引：25

作者：

DE, AK

AGARWAL, K

MUKHERJEE, A

SENGUPTA, D

机构：

[1] UNIV COLL SCI CALCUTTA,DEPT BIOCHEM,CALCUTTA 700019,W BENGAL,INDIA

[2] UNIV CALCUTTA,CTR ADV STUDY CELL & CHROMOSOME RES,DEPT BOT,CALCUTTA 700019,W BENGAL,INDIA

来源：

MUTATION RESEARCH-ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS | 1995年 / 335卷 / 03期

关键词：

CAPSAICIN; CHROMOSOMAL ABERRATION; DNA DAMAGE; CYCLOPHOSPHAMIDE; ANTAGONISM;

D O I：

10.1016/0165-1161(95)00028-3

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

We have demonstrated in an earlier paper that capsaicin, the pungent principle of red hot chilli, has a potent anti-oxidant property that interferes with free-radical involved mechanisms. In the present paper we demonstrate that capsaicin significantly inhibits cyclophosphamide-induced (i.p.) chromosomal aberrations and DNA strand breakages. This protective action of capsaicin against CP-induced toxicity may possibly be linked with its already reported 'desensitisation' effect against chemical irritant-induced damages.

引用

页码：253 / 258

页数：6

共 18 条

[1]

AGARWAL RC, 1988, INDIAN J EXP BIOL, V26, P377

[2]

AGARWAL RC, 1986, INT J CANCER, V68, P689

[3]

BIRNBOIM HC, 1981, CANCER RES, V41, P1889

[4] STUDIES ON CAPSAICIN INHIBITION OF CHEMICALLY-INDUCED LIPID-PEROXIDATION IN THE LUNG AND LIVER-TISSUES OF RAT [J].