ALZHEIMER-DISEASE - AN IMBALANCE OF PROTEOLYTIC REGULATION

被引：26

作者：

SMITH, MA

PERRY, G

机构：

[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901

来源：

MEDICAL HYPOTHESES | 1994年 / 42卷 / 04期

关键词：

D O I：

10.1016/0306-9877(94)90132-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alzheimer disease is typified by the accumulation of protein and neuronal death. We propose that neuronal death creates a proteolytic imbalance that generates the pathological lesions. Our hypothesis explains the morphology and topographic distribution of neuritic plaques and neurofibrillary tangles.

引用

页码：277 / 279

页数：3

共 27 条

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