ALZHEIMER-DISEASE - AN IMBALANCE OF PROTEOLYTIC REGULATION

被引：26

作者：

SMITH, MA

PERRY, G

机构：

[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106-4901

来源：

MEDICAL HYPOTHESES | 1994年 / 42卷 / 04期

关键词：

D O I：

10.1016/0306-9877(94)90132-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Alzheimer disease is typified by the accumulation of protein and neuronal death. We propose that neuronal death creates a proteolytic imbalance that generates the pathological lesions. Our hypothesis explains the morphology and topographic distribution of neuritic plaques and neurofibrillary tangles.

引用

页码：277 / 279

页数：3

共 27 条

[11]

KALARIA RN, 1993, IN PRESS AM J PATHOL

[12]

KAWAI M, 1990, AM J PATHOL, V137, P1435

[13] ALZHEIMERS DISEASE - ELECTRON MICROSCOPICAL STUDY [J].

KIDD, M .

BRAIN, 1964, 87 (02) :307-&

[14] ENZYME SPECIFICITY OF PROTEINASE-INHIBITOR REGION IN AMYLOID PRECURSOR PROTEIN OF ALZHEIMERS-DISEASE - DIFFERENT PROPERTIES COMPARED WITH PROTEASE NEXIN-I [J].

KITAGUCHI, N ;

TAKAHASHI, Y ;

OISHI, K ;

SHIOJIRI, S ;

TOKUSHIMA, Y ;

UTSUNOMIYA, T ;

ITO, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1038 (01) :105-113

[15] NOVEL PRECURSOR OF ALZHEIMERS-DISEASE AMYLOID PROTEIN SHOWS PROTEASE INHIBITORY ACTIVITY [J].

KITAGUCHI, N ;

TAKAHASHI, Y ;

TOKUSHIMA, Y ;

SHIOJIRI, S ;

ITO, H .

NATURE, 1988, 331 (6156) :530-532

[16] A METALLOPROTEINASE INHIBITOR DOMAIN IN ALZHEIMER AMYLOID PROTEIN-PRECURSOR [J].

MIYAZAKI, K ;

HASEGAWA, M ;

FUNAHASHI, K ;

UMEDA, M .

NATURE, 1993, 362 (6423) :839-841

[17]

MIYAZAKI K, 1982, P NATL ACAD SCI USA, V79, P3210

[18] ANATOMICAL CORRELATES OF THE DISTRIBUTION OF THE PATHOLOGICAL-CHANGES IN THE NEOCORTEX IN ALZHEIMER-DISEASE [J].

PEARSON, RCA ;

ESIRI, MM ;

HIORNS, RW ;

WILCOCK, GK ;

POWELL, TPS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (13) :4531-4534

[19]

PERRY G, 1987, P NATL ACAD SCI USA, V84, P303

[20]

PERRY G, 1992, NEUROSCIENCE YEAR, P5

← 1 2 3 →