TELOMERES AND TELOMERASE IN AGING AND CANCER

被引：300

作者：

HARLEY, CB

VILLEPONTEAU, B

机构：

[1] Geron Corporation, Menlo Park, CA 94025

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1016/0959-437X(95)80016-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Telomeres are maintained by the novel ribonucleoprotein enzyme telomerase. Telomerase activity is repressed in most somatic human cells, leading to telomere loss during replicative aging in-vivo and in vitro. However, telomerase appears to be reactivated in essentially all human cancers. With the recent cloning of the RNA component of telomerase from several species, the stage is now set for critical tests of the role of telomeres and telomerase in aging and cancer.

引用

页码：249 / 255

页数：7

共 56 条

[1] HUMAN TELOMERES CONTAIN AT LEAST 3 TYPES OF G-RICH REPEAT DISTRIBUTED NON-RANDOMLY
ALLSHIRE, RC
DEMPSTER, M
HASTIE, ND
[J]. NUCLEIC ACIDS RESEARCH, 1989, 17 (12) : 4611 - 4627
[2] TELOMERE LENGTH PREDICTS REPLICATIVE CAPACITY OF HUMAN FIBROBLASTS
ALLSOPP, RC
VAZIRI, H
PATTERSON, C
GOLDSTEIN, S
YOUNGLAI, EV
FUTCHER, AB
GREIDER, CW
HARLEY, CB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) : 10114 - 10118
[3] FUNCTIONAL RECONSTITUTION OF WILD-TYPE AND MUTANT TETRAHYMENA TELOMERASE
AUTEXIER, C
GREIDER, CW
[J]. GENES & DEVELOPMENT, 1994, 8 (05) : 563 - 575
[4] TELOMERES - NO END IN SIGHT
BLACKBURN, EH
[J]. CELL, 1994, 77 (05) : 621 - 623
[5] TELOMERASES
BLACKBURN, EH
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1992, 61 : 113 - 129
[6] RAP1 PROTEIN INTERACTS WITH YEAST TELOMERES INVIVO - OVERPRODUCTION ALTERS TELOMERE STRUCTURE AND DECREASES CHROMOSOME STABILITY
CONRAD, MN
WRIGHT, JH
WOLF, AJ
ZAKIAN, VA
[J]. CELL, 1990, 63 (04) : 739 - 750
[7] TELOMERASE ACTIVITY IN HUMAN OVARIAN-CARCINOMA
COUNTER, CM
HIRTE, HW
BACCHETTI, S
HARLEY, CB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) : 2900 - 2904
[8] TELOMERE SHORTENING ASSOCIATED WITH CHROMOSOME INSTABILITY IS ARRESTED IN IMMORTAL CELLS WHICH EXPRESS TELOMERASE ACTIVITY
COUNTER, CM
AVILION, AA
LEFEUVRE, CE
STEWART, NG
GREIDER, CW
HARLEY, CB
BACCHETTI, S
[J]. EMBO JOURNAL, 1992, 11 (05) : 1921 - 1929
[9] STABILIZATION OF SHORT TELOMERES AND TELOMERASE ACTIVITY ACCOMPANY IMMORTALIZATION OF EPSTEIN-BARR VIRUS-TRANSFORMED HUMAN B-LYMPHOCYTES
COUNTER, CM
BOTELHO, FM
WANG, P
HARLEY, CB
BACCHETTI, S
[J]. JOURNAL OF VIROLOGY, 1994, 68 (05) : 3410 - 3414
[10] STRUCTURE AND VARIABILITY OF HUMAN-CHROMOSOME ENDS
DELANGE, T
SHIUE, L
MYERS, RM
COX, DR
NAYLOR, SL
KILLERY, AM
VARMUS, HE
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (02) : 518 - 527

← 1 2 3 4 5 6 →