GENETIC-MAPPING OF THE MOUSE X-CHROMOSOME IN THE REGION HOMOLOGOUS TO HUMAN XQ27-XQ28

被引：26

作者：

HERMAN, GE

FAUST, CJ

DARLISON, MG

BARNARD, EA

机构：

[1] BAYLOR UNIV,DEPT PEDIAT,HOUSTON,TX 77030

[2] MRC,MRC MOLEC NEUROBIOL UNIT,CAMBRIDGE CB2 2QH,ENGLAND

来源：

GENOMICS | 1991年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(91)90360-Q

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The four loci Gabra3, DXPas8, CamL1, and Bpa, located near the murine X-linked visual pigment gene (Rsup), have been ordered using 248 backcross progeny from an interspecific mating of ( B6CBA-Aw-J A-Bpa) and Mus spretus. One hundred twenty backcross progeny have been analyzed at seven anchor loci spanning the X chromosome and form a regional mapping panel. An additional 128 progeny have been screened for recombination events between Cf-9 and Dmd. Eighteen recombinants between these loci have been detected in the 248 animals; all of the recombinants were screened at the other anchor loci to identify any double crossovers. Pedigree analysis using these recombinants strongly favors a gene order of (Cf-9)-Gabra3-(DXPas8, Bpa)-CamL1-(Rsvp, P3, Cf-8)-Dmd for the loci studied. Synteny with human Xq27-Xq28 is retained, although the relative order of some loci may differ between the two species. © 1991.

引用

页码：670 / 677

页数：8

共 34 条

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