SELECTIVE ENHANCEMENT BY BASIC FIBROBLAST GROWTH-FACTOR OF NMDA RECEPTOR-MEDIATED INCREASE OF INTRACELLULAR CA2+ CONCENTRATION IN HIPPOCAMPAL-NEURONS

被引:17
作者
ABE, K
SAITO, H
机构
[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Tokyo
关键词
BASIC FIBROBLAST GROWTH FACTOR; INTRACELLULAR CA2+ CONCENTRATION; HIPPOCAMPAL NEURON; NMDA RECEPTOR; NON-NMDA RECEPTOR; LONG-TERM POTENTIATION;
D O I
10.1016/0006-8993(92)91461-M
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The short-term effect of bFGF on intracellular Ca2+ concentration ([Ca2+]i) of hippocampal neurons was investigated using dissociated cell cultures. Changes in [Ca2+]i were measured by microfluorometrically monitoring the fluorescence intensities from individual neurons loaded with fura-2. Perfusion of bFGF (20 ng/ml) alone did not affect the basal level of [Ca2+]i in hippocampal neurons, but clearly enhanced the [Ca2+]i increase induced by NMDA. Quisqualate or KCl-induced [Ca2+]i increase was not influenced by bFGF. These results suggest that bFGF selectively enhances the NMDA receptor-mediated response in hippocampal neurons.
引用
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页码:128 / 132
页数:5
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