The short-term effect of bFGF on intracellular Ca2+ concentration ([Ca2+]i) of hippocampal neurons was investigated using dissociated cell cultures. Changes in [Ca2+]i were measured by microfluorometrically monitoring the fluorescence intensities from individual neurons loaded with fura-2. Perfusion of bFGF (20 ng/ml) alone did not affect the basal level of [Ca2+]i in hippocampal neurons, but clearly enhanced the [Ca2+]i increase induced by NMDA. Quisqualate or KCl-induced [Ca2+]i increase was not influenced by bFGF. These results suggest that bFGF selectively enhances the NMDA receptor-mediated response in hippocampal neurons.
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SENO, M
SASADA, R
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SASADA, R
IWANE, M
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
IWANE, M
SUDO, K
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SUDO, K
KUROKAWA, T
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
KUROKAWA, T
ITO, K
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
ITO, K
IGARASHI, K
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SENO, M
SASADA, R
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SASADA, R
IWANE, M
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
IWANE, M
SUDO, K
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
SUDO, K
KUROKAWA, T
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
KUROKAWA, T
ITO, K
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h-index: 0
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN
ITO, K
IGARASHI, K
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h-index: 0
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TAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPANTAKEDA CHEM IND LTD, DIV CENT RES, BIOL RES LABS, YODOGAWA KU, OSAKA 532, JAPAN