SIGNAL-TRANSDUCTION AND CELL FATE SPECIFICATION DURING CAENORHABDITIS-ELEGANS VULVAR DEVELOPMENT

被引：47

作者：

EISENMANN, DM

KIM, SK

机构：

[1] Department of Developmental Biology, Beckman Center B300, Stanford University Medical Center, Stanford

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/0959-437X(94)90065-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.

引用

页码：508 / 516

页数：9

共 70 条

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