SIGNAL-TRANSDUCTION AND CELL FATE SPECIFICATION DURING CAENORHABDITIS-ELEGANS VULVAR DEVELOPMENT

被引：47

作者：

EISENMANN, DM

KIM, SK

机构：

[1] Department of Developmental Biology, Beckman Center B300, Stanford University Medical Center, Stanford

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 04期

关键词：

D O I：

10.1016/0959-437X(94)90065-B

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.

引用

收藏

页码：508 / 516

页数：9

相关论文

共 70 条

[41] THE SH2 AND SH3 DOMAIN CONTAINING PROTEIN GRB2 LINKS RECEPTOR TYROSINE KINASES TO RAS SIGNALING [J].

LOWENSTEIN, EJ ;

DALY, RJ ;

BATZER, AG ;

LI, W ;

MARGOLIS, B ;

LAMMERS, R ;

ULLRICH, A ;

SKOLNIK, EY ;

BARSAGI, D ;

SCHLESSINGER, J .

CELL, 1992, 70 (03) :431-442

[42] THE SRF ACCESSORY PROTEIN ELK-1 CONTAINS A GROWTH FACTOR-REGULATED TRANSCRIPTIONAL ACTIVATION DOMAIN [J].

MARAIS, R ;

WYNNE, J ;

TREISMAN, R .

CELL, 1993, 73 (02) :381-393

[43] SIGNAL TRANSDUCTION - HOW RECEPTORS TURN RAS ON [J].

MCCORMICK, F .

NATURE, 1993, 363 (6424) :15-16

[44] LIN-31, A CAENORHABDITIS-ELEGANS HNF-3 FORK-HEAD TRANSCRIPTION FACTOR HOMOLOG, SPECIFIES 3 ALTERNATIVE CELL FATES IN VULVAR DEVELOPMENT [J].

MILLER, LM ;

GALLEGOS, ME ;

MORISSEAU, BA ;

KIM, SK .

GENES & DEVELOPMENT, 1993, 7 (06) :933-947

[45] 2 NOVEL TRANSMEMBRANE PROTEIN-TYROSINE KINASES EXPRESSED DURING CAENORHABDITIS-ELEGANS HYPODERMAL DEVELOPMENT [J].

MORGAN, WR ;

GREENWALD, I .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (11) :7133-7143

[46] PHOSPHORYLATION AT THREONINE-235 BY A RAS-DEPENDENT MITOGEN-ACTIVATED PROTEIN-KINASE CASCADE IS ESSENTIAL FOR TRANSCRIPTION FACTOR NF-IL6 [J].

NAKAJIMA, T ;

KINOSHITA, S ;

SASAGAWA, T ;

SASAKI, K ;

NARUTO, M ;

KISHIMOTO, T ;

AKIRA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (06) :2207-2211

[47] THE MAP KINASE CASCADE IS ESSENTIAL FOR DIVERSE SIGNAL TRANSDUCTION PATHWAYS [J].

NISHIDA, E ;

GOTOH, Y .

TRENDS IN BIOCHEMICAL SCIENCES, 1993, 18 (04) :128-131

[48] A DROSOPHILA SH2-SH3 ADAPTER PROTEIN IMPLICATED IN COUPLING THE SEVENLESS TYROSINE KINASE TO AN ACTIVATOR OF RAS GUANINE-NUCLEOTIDE EXCHANGE, SOS [J].

OLIVIER, JP ;

RAABE, T ;

HENKEMEYER, M ;

DICKSON, B ;

MBAMALU, G ;

MARGOLIS, B ;

SCHLESSINGER, J ;

HAFEN, E ;

PAWSON, T .

CELL, 1993, 73 (01) :179-191

[49] MAP KINASES - CHARTING THE REGULATORY PATHWAYS [J].

PELECH, SL ;

SANGHERA, JS .

SCIENCE, 1992, 257 (5075) :1355-1356

[50] THE TORSO RECEPTOR PROTEIN-TYROSINE KINASE SIGNALING PATHWAY - AN ENDLESS STORY [J].

PERRIMON, N .

CELL, 1993, 74 (02) :219-222

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