LEPTOSIN-I AND LEPTOSIN-J, CYTOTOXIC SUBSTANCES PRODUCED BY A LEPTOSPHAERIA SP - PHYSICOCHEMICAL PROPERTIES AND STRUCTURES

被引：52

作者：

TAKAHASHI, C

NUMATA, A

MATSUMURA, E

MINOURA, K

ETO, H

SHINGU, T

ITO, T

HASEGAWA, T

机构：

[1] OSAKA UNIV PHARMACEUT SCI,MATSUBARA,OSAKA 580,JAPAN

[2] KOBE GAKUIN UNIV,DEPT PHARMACEUT SCI,NISHI KU,KOBE 673,JAPAN

[3] INST FERMENTAT,YODOGAWA KU,OSAKA 532,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 11期

关键词：

D O I：

10.7164/antibiotics.47.1242

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Leptosins I and J, belonging to a series of epipolythiodioxopiperazines, have been isolated from the mycelium of a strain of Leptosphaeria sp. OUPS-4 attached to the marine alga Sargasssum tortile. Their relative stereostructures have been elucidated by chemical and spectral evidence. These compounds exhibited significant cytotoxic activity against cultured P388 cells.

引用

页码：1242 / 1249

页数：8