POTENTIAL ANTIMALARIALS .10. DI-MANNICH BASES OF 4-(7'-TRIFLUOROMETHYL-1',5'-NAPHTHYRIDIN-4'-YLAMINO)PHENOL AND N-(4'-DIETHYLAMINO-1'-METHYLBUTYL)-7-TRIFLUOROMETHYL-1,5-NAPHTHYRIDIN-4-AMINE

被引：24

作者：

BARLIN, GB

JIRAVINYU, C

机构：

[1] Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 1990年 / 43卷 / 07期

关键词：

D O I：

10.1071/CH9901175

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The syntheses of some di-Mannich bases derived from 4-(7′-trifluoromethyl-l′)5′-naphthyridin-4′- ylamino) phenol and of N-(4′-diethylamino-l′-methylbutyl)-7-trifluoromethyl-l, 5-naphthyridin- 4-amine from 3-chloro-5-trifluoromethylpyridine via 4-chloro-7-trifluoromethyl-l, 5-naphthyrid- ine are described. In tests in vitro against the fcq-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues. © 1990 ASEG.

引用

页码：1175 / 1181

页数：7

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