VASOACTIVE INTESTINAL POLYPEPTIDE MODULATES NEURONAL EXCITABILITY IN HIPPOCAMPAL SLICES OF THE RAT

被引：51

作者：

HAAS, HL ^{[1
]}

GAHWILER, BH ^{[1
]}

机构：

[1] BRAIN RES INST,CH-8029 ZURICH,SWITZERLAND

来源：

NEUROSCIENCE | 1992年 / 47卷 / 02期

关键词：

D O I：

10.1016/0306-4522(92)90243-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Vasoactive intestinal polypeptide added at submicromolar concentrations to the perfusion fluid of rat hippocampal slices and slice cultures enhanced the excitability of CA1 and CA3 pyramidal cells in several ways. Specifically, cells were depolarized and the Ca2+- and cyclic AMP-dependent potassium conductance was blocked as demonstrated by reduction of the long-lasting afterhyperpolarization and the accommodation of firing. This was also found in tetrodotoxin-containing medium. In low Ca2+-high Mg2+ medium (in synaptic isolation) the firing rate was increased. Synaptic transmission was potentiated: extracellularly registered excitatory postsynaptic potentials and population spikes in response to stratum radiatum stimulation and intracellularly recorded excitatory postsynaptic potential inhibitory postsynaptic potential sequences were enhanced. These results are in keeping with the known stimulation of adenylate cyclase by vasoactive intestinal polypeptide.

引用

页码：273 / 277

页数：5

共 25 条

[11] MEMBRANE-PROPERTIES, RESPONSE TO AMINES AND TO TETANIC STIMULATION OF HIPPOCAMPAL-NEURONS IN THE GENETICALLY EPILEPTIC MUTANT MOUSE TOTTERING [J].