A 28 KDA-PROTEIN WITH DISINTEGRIN-LIKE STRUCTURE (JARARHAGIN-C) PURIFIED FROM BOTHROPS-JARARACA VENOM INHIBITS COLLAGEN-INDUCED AND ADP-INDUCED PLATELET-AGGREGATION

被引：114

作者：

USAMI, Y

FUJIMURA, Y

MIURA, S

SHIMA, H

YOSHIDA, E

YOSHIOKA, A

HIRANO, K

SUZUKI, M

TITANI, K

机构：

[1] FUJITA HLTH UNIV, INST COMPREHENS MED SCI, DIV BIOMED POLYMER SCI, TOYOAKE, AICHI 47011, JAPAN

[2] GIFU PHARMACEUT UNIV, DEPT PHARMACEUT, GIFU 502, JAPAN

[3] NARA MED UNIV, DEPT BLOOD TRANSFUS, KASHIHARA, NARA 634, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 01期

关键词：

D O I：

10.1006/bbrc.1994.1706

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 28 kDa-protein with inhibitory activity on collagen- and ADP-induced platelet aggregation was purified from the venom of the snake Bothrops jararaca. Its complete amino acid sequence corresponded to the carboxyl-terminal region consisting of disintegrin-like and cysteine-rich domains of jararhagin, a high molecular weight hemorrhagic metalloprotease. Sequence homology of the protein to other disintegrins and disintegrin-like proteins from various snake venoms is also presented. (C) 1994 Academic Press, Inc.

引用

页码：331 / 339

页数：9