INHIBITION OF POSTERIOR CAPSULE OPACIFICATION - THE EFFECT OF COLCHICINE IN A SUSTAINED DRUG-DELIVERY SYSTEM

被引：73

作者：

LEGLER, UFC ^{[1
]}

APPLE, DJ ^{[1
]}

ASSIA, EI ^{[1
]}

BLUESTEIN, EC ^{[1
]}

CASTANEDA, VE ^{[1
]}

MOWBRAY, SL ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT OPHTHALMOL,INST STORM EYE,CTR INTRAOCULAR LENS RES,CHARLESTON,SC 29425

来源：

JOURNAL OF CATARACT AND REFRACTIVE SURGERY | 1993年 / 19卷 / 04期

关键词：

COLCHICINE; INHIBITION; POSTERIOR CAPSULE OPACIFICATION; SUSTAINED DRUG DELIVERY SYSTEM;

D O I：

10.1016/S0886-3350(13)80609-8

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We investigated the effect of colchicine in a sustained drug delivery system on posterior capsule opacification (PCO) in rabbit eyes. A polymer matrix wafer, which diffused colchicine at a steady rate, was implanted in the capsular bag of 34 eyes after the lens material was removed by endocapsular phacoemulsification. Three different drug concentrations were used in the rabbit eyes, which were compared with control eyes containing the polymer matrix wafer without colchicine. The mean PCO score was highest in the control group without colchicine and increased steadily over 12 weeks. The rate of PCO formation in all eyes treated with colchicine was significantly lower than in the control group. There was no statistically significant improvement in PCO inhibition with the higher colchicine dosages. Side effects included inflammatory anterior chamber reaction and corneal and retinal complications and were most notable with the highest drug concentration. Slow release of colchicine reduces PCO formation in the rabbit. The optimal biocompatible dosage must be carefully determined and warrants further investigation.

引用

页码：462 / 470

页数：9

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