CARRAGEENAN-INDUCED GRANULOMA AND IRON STATUS IN RATS WITH DIETARY POLYUNSATURATED FATTY-ACID DEFICIENCY

被引：10

作者：

CARBONELL, T

SAIZ, MP

MITJAVILA, MT

PUIGPARELLADA, P

CAMBONGROS, C

FERNANDEZ, Y

MITJAVILA, S

机构：

[1] UNIV BARCELONA,FAC BIOL,DEPT BIOQUIM & FISIOL,AVE DIAGONAL 645,E-08071 BARCELONA,SPAIN

[2] UNIV BARCELONA,FAC MED,DEPT FARMACOL,E-08028 BARCELONA,SPAIN

[3] UNIV TOULOUSE 3,INST PHYSIOL,INSERM,U87,F-31400 TOULOUSE,FRANCE

来源：

BRITISH JOURNAL OF NUTRITION | 1991年 / 65卷 / 03期

关键词：

FATTY ACIDS; IRON STATUS; CARRAGEENAN-INDUCED GRANULOMA; RAT;

D O I：

10.1079/BJN19910108

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Sprague-Dawley rats were fed for 4 months on a control diet or a polyunsaturated-fatty-acid (PUFA)-deficient diet. The combined effects of iron overload (Fe dextran) or Fe deficiency (desferrioxamine) on carrageenan-induced granuloma were studied. PUFA deficiency induced changes in Fe metabolism, but no alterations in lipid peroxidation variables were observed. Inflammation implied an increase in lipid peroxidation, Fe storage and caeruloplasmin concentration, together with symptoms of anaemia. PUFA deficiency in inflamed rats gave rise to a lower inflammatory response (granuloma weight and prostaglandin E, concentration) and ethane exhalation. Fe overload potentiated inflammatory and lipid peroxidation processes, whereas Fe deficiency decreased them.

引用

页码：497 / 503

页数：7

共 34 条

[1] IDENTIFICATION OF 4-HYDROXYNONEAL AS A CYTO-TOXIC PRODUCT ORIGINATING FROM THE PEROXIDATION OF LIVER MICROSOMAL LIPIDS [J].