CONSERVED REGULATORY ELEMENTS IN THE TYPE-I DNA TOPOISOMERASE GENE PROMOTERS OF MOUSE AND MAN

被引:10
作者
BAUMGARTNER, B [1 ]
HEILAND, S [1 ]
KUNZE, N [1 ]
RICHTER, A [1 ]
KNIPPERS, R [1 ]
机构
[1] UNIV KONSTANZ,DIV BIOL,D-78434 CONSTANCE,GERMANY
来源
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1994年 / 1218卷 / 01期
关键词
REGULATORY ELEMENT; TRANSCRIPTION CONTROL; DNA TOPOISOMERASE GENE; (MOUSE); (HUMAN);
D O I
10.1016/0167-4781(94)90114-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gene for mammalian type I DNA topoisomerase is constitutively expressed, but also regulated by a number of external stimuli. We compared the nucleotide sequences of the human and the mouse topoisomerase I gene promoters because promoter elements, essential for basic as well as regulated gene expression, should be conserved during evolution. We found that proximal upstream sequences are highly conserved and include potential binding sites for ubiquitous transcription factors, a regulatory CRE site as well as two novel promoter elements that have been shown to be important for the expression of the human gene. The more distal parts of the upstream sequences are less well conserved but include two regions that are almost identical in the human and the mouse gene. One of these regions contains a binding site for a basic-helix-loop-helix/leucine-zipper protein, and the other contains an AT-rich element with the potential for DNA bending.
引用
收藏
页码:123 / 127
页数:5
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