CLONING OF THE MOUSE CDNA-ENCODING DNA TOPOISOMERASE-I AND CHROMOSOMAL LOCATION OF THE GENE

被引：23

作者：

KOIWAI, O

YASUI, Y

SAKAI, Y

WATANABE, T

ISHII, K

YANAGIHARA, S

ANDOH, T

机构：

[1] AICHI PREFECTURAL COLONY,INST DEV RES,KASUGAI,AICHI 48003,JAPAN

[2] MEIJI COLL PHARM,DEPT HYG CHEM,TANASHI,TOKYO 188,JAPAN

来源：

GENE | 1993年 / 125卷 / 02期

关键词：

D O I：

10.1016/0378-1119(93)90331-V

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse cDNA encoding DNA topoisomerase I (TopoI) was cloned and the nucleotide sequence of 3512 bp was determined. The cDNA clone contained an open reading frame encoding a protein of 767 amino acids (aa), which is 2 aa longer than its human counterpart. Overall aa sequence homology between the mouse and human, and between the mouse and yeast (Saccharomyces cerevisiae) sequences was 96% and 42%, respectively. The mouse TopI gene was mapped at position 54.5 on chromosome 2 from linkage analyses of a three-point cross test with Gcg, Ada, and a as marker genes.

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页码：211 / 216

页数：6

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