SERUM LEVELS OF INTERFERON-GAMMA, CYTOTOXIC FACTOR AND SOLUBLE INTERLEUKIN-2 RECEPTOR IN CHILDHOOD HEMOPHAGOCYTIC SYNDROMES

被引：61

作者：

IMASHUKU, S

IKUSHIMA, S

ESUMI, N

TODO, S

SAITO, M

机构：

[1] Division of Pediatrics, Children's Research Hospital, and Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto

[2] Applied Research Laboratory of Chugai Pharmaceutical Co. Ltd., Tokyo

来源：

LEUKEMIA & LYMPHOMA | 1991年 / 3卷 / 04期

关键词：

INTERFERON-GAMMA; CYTOTOXIC FACTOR; SOLUBLE INTERLEUKIN-2 RECEPTOR; MALIGNANT HISTIOCYTOSIS; VIRUS-ASSOCIATED HEMOPHAGOCYTIC SYNDROME;

D O I：

10.3109/10428199109107916

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum levels of interferon (IFN)-gamma, cytotoxic factor (CF) and soluble interleukin-2 receptor (sIL2R) were assayed in relation to hyperferritinemia in eleven cases of malignant histiocytosis (MH), seven of virus-associated hemophagocytic syndrome (VAHS) and one of familial erythrophagocytic lymphohistiocytosis (FEL). IFN-gamma was markedly elevated (>10,000 U/ml) in 5 MH cases and only in one case of VAHS. CF was significantly elevated (> 150 U/ml) in 5 MH and 4 VAHS/FEL patients. sIL2R were remarkably elevated (> 10,000 U/ml) in 5 MH and 4 VAHS patients. In individual cases, the patterns of these parameters were quite different, suggesting the existence of a variable pathophysiology in cases with hemophagocytic syndromes. In terms of the patients' outcome, high IFN-gamma or sIL2R levels were associated with a poor prognosis while high CF appeared to be associated with a better prognosis. © 1991 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：287 / 292

页数：6

共 32 条

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