INTERLEUKIN-1-BETA INDUCES CORTICOTROPIN-RELEASING FACTOR-41 RELEASE FROM CULTURED HYPOTHALAMIC CELLS THROUGH PROTEIN-KINASE-C AND CAMP-DEPENDENT PROTEIN-KINASE PATHWAYS

被引：22

作者：

HU, SB

TANNAHILL, LA

LIGHTMAN, SL

机构：

[1] Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1992年 / 40卷 / 01期

关键词：

INTERLEUKIN-1-BETA; CORTICOTROPIN-RELEASING FACTOR-41; PROTEIN KINASE-C; CAMP-DEPENDENT PROTEIN KINASE; DEXAMETHASONE;

D O I：

10.1016/0165-5728(92)90212-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-1-beta (IL-1-beta) induces a dose-dependent increase in the release of corticotropin-releasing factor-41 (CRF) from dispersed rat fetal hypothalamic cells in culture. This release of CRF could be inhibited by the protein kinase C inhibitor H-7, and by the protein kinase A inhibitor IP-20. This suggests that both protein kinase C and protein kinase A-dependent pathways are involved in the response of CRF to IL-1-beta. Dexamethasone also blocked the CRF response to IL-1-beta, indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1-beta.

引用

页码：49 / 56

页数：8

共 48 条

[1]

ACKLAND JF, 1986, J ENDOCRINOL, V108, P3171

[2] INTRAHYPOTHALAMIC INFUSION OF INTERLEUKIN-1-BETA INCREASES THE RELEASE OF CORTICOTROPIN-RELEASING HORMONE (CRH-41) AND ADRENOCORTICOTROPIC HORMONE (ACTH) IN FREE-MOVING RATS BEARING A PUSH-PULL CANNULA IN THE MEDIAN-EMINENCE [J].