INTERLEUKIN-1-BETA INDUCES CORTICOTROPIN-RELEASING FACTOR-41 RELEASE FROM CULTURED HYPOTHALAMIC CELLS THROUGH PROTEIN-KINASE-C AND CAMP-DEPENDENT PROTEIN-KINASE PATHWAYS

被引:22
作者
HU, SB
TANNAHILL, LA
LIGHTMAN, SL
机构
[1] Neuroendocrinology Unit, Charing Cross and Westminster Medical School, Charing Cross Hospital, London
关键词
INTERLEUKIN-1-BETA; CORTICOTROPIN-RELEASING FACTOR-41; PROTEIN KINASE-C; CAMP-DEPENDENT PROTEIN KINASE; DEXAMETHASONE;
D O I
10.1016/0165-5728(92)90212-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interleukin-1-beta (IL-1-beta) induces a dose-dependent increase in the release of corticotropin-releasing factor-41 (CRF) from dispersed rat fetal hypothalamic cells in culture. This release of CRF could be inhibited by the protein kinase C inhibitor H-7, and by the protein kinase A inhibitor IP-20. This suggests that both protein kinase C and protein kinase A-dependent pathways are involved in the response of CRF to IL-1-beta. Dexamethasone also blocked the CRF response to IL-1-beta, indicating that activated glucocorticoid receptors can inhibit the response of CRF to IL-1-beta.
引用
收藏
页码:49 / 56
页数:8
相关论文
共 48 条
[21]   RELEASE OF CORTICOTROPIN-RELEASING FACTOR-41, ARGININE VASOPRESSIN AND OXYTOCIN FROM RAT FETAL HYPOTHALAMIC CELLS IN CULTURE - RESPONSE TO ACTIVATION OF INTRACELLULAR SECOND MESSENGERS AND TO CORTICOSTEROIDS [J].
HU, SB ;
TANNAHILL, LA ;
BISWAS, S ;
LIGHTMAN, SL .
JOURNAL OF ENDOCRINOLOGY, 1992, 132 (01) :57-65
[22]  
HU SB, 1991, IN PRESS NEUROENDOCR
[23]   EFFECTS OF ADRENALECTOMY AND DEXAMETHASONE ADMINISTRATION ON THE LEVEL OF PREPRO-CORTICOTROPIN-RELEASING FACTOR MESSENGER RIBONUCLEIC-ACID (MESSENGER-RNA) IN THE HYPOTHALAMUS AND "ADRENOCORTICOTROPIN-BETA-LIPOTROPIN PRECURSOR MESSENGER-RNA IN THE PITUITARY IN RATS [J].
JINGAMI, H ;
MATSUKURA, S ;
NUMA, S ;
IMURA, H .
ENDOCRINOLOGY, 1985, 117 (04) :1314-1320
[24]   IL1 INDUCES PROLIFERATION AND IL6 MESSENGER-RNA EXPRESSION IN A HUMAN ASTROCYTOMA CELL-LINE - POSITIVE AND NEGATIVE MODULATION BY CHORELA TOXIN AND CAMP [J].
KASAHARA, T ;
YAGISAWA, H ;
YAMASHITA, K ;
YAMAGUCHI, Y ;
AKIYAMA, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 167 (03) :1242-1248
[25]   IDENTIFICATION OF A HIGH-AFFINITY RECEPTOR FOR INTERLEUKIN-1-BETA IN RAT-BRAIN [J].
KATSUURA, G ;
GOTTSCHALL, PE ;
ARIMURA, A .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 156 (01) :61-67
[26]   CORTICOSTEROID INHIBITION OF ACTH-SECRETION [J].
KELLERWOOD, ME ;
DALLMAN, MF .
ENDOCRINE REVIEWS, 1984, 5 (01) :1-24
[27]   DEXAMETHASONE INHIBITION OF INTERLEUKIN-1 BETA-PRODUCTION BY HUMAN-MONOCYTES - POSTTRANSCRIPTIONAL MECHANISMS [J].
KERN, JA ;
LAMB, RJ ;
REED, JC ;
DANIELE, RP ;
NOWELL, PC .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (01) :237-244
[28]  
KNUDSEN PJ, 1987, J IMMUNOL, V139, P4129
[29]   GLUCOCORTICOID IMPLANTS AROUND THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS PREVENT THE INCREASE OF CORTICOTROPIN-RELEASING FACTOR AND ARGININE VASOPRESSIN IMMUNOSTAINING INDUCED BY ADRENALECTOMY [J].
KOVACS, K ;
KISS, JZ ;
MAKARA, GB .
NEUROENDOCRINOLOGY, 1986, 44 (02) :229-234
[30]   LACTATION INHIBITS STRESS-MEDIATED SECRETION OF CORTICOSTERONE AND OXYTOCIN AND HYPOTHALAMIC ACCUMULATION OF CORTICOTROPIN-RELEASING FACTOR AND ENKEPHALIN MESSENGER RIBONUCLEIC-ACIDS [J].
LIGHTMAN, SL ;
YOUNG, WS .
ENDOCRINOLOGY, 1989, 124 (05) :2358-2364